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Our research focuses on the relationship between metabolism, hypoxia and the diabetic heart.  We have investigated the mechanisms the heart employs to adapt to a decrease in oxygen availability, regulating changes within mitochondrial oxidative and anaerobic glycolytic metabolism. We have shown that metabolic adaptation to hypoxia is abnormal in the type 2 diabetic heart, and have identified some of the mechanisms involved.  We are employing various pharmacological strategies to correct these processes, both directly via metabolic modulators, and indirectly via activation of hypoxic signalling pathways.  These strategies may provide an approach to improve ischemic recovery in the diabetic heart.

If you have a question about this talk, please contact Sarah Noujaim.