Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we will assume that you are happy to receive all cookies and you will not see this message again. Click 'Find out more' for information on how to change your cookie settings.


Gratz et al. (2013) Genetics "Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease" [Pubmed]

Bassett et al. (2013) Cell Reports "Highly efficient targeted mutagenesis of Drosophila with the CRISPR/Cas9 system" [Pubmed]

Yu, Ren et al. (2013) Genetics "Highly efficient genome modifications mediated by CRISPR/Cas9 in Drosophila" [Pubmed]

Kondo and Ueda. (2013) Genetics "Highly improved gene targeting by germline-specific Cas9 expression in Drosophila" [Pubmed]

Sebo et al. (2013) Fly "A simplified and efficient germline-specific CRISPR/Cas9 system for Drosophila genomic engineering" [Pubmed]

Ren et al. (2013) PNAS "Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9" [Pubmed]

Bassett et al. (2013) Biology Open "Mutagenesis and homologous recombination in Drosophila cell lines using CRISPR/Cas9" [Pubmed]

Bassett AR and Liu JL. (2013). CRISPR/Cas9 and genome editing in Drosophila. Journal of Genetics and Genomics [Epub ahead of print 18 Dec 2013][doi:10.1016/j.jgg.2013.12.004][POSTER: Timeline of CRISPR Research]

Homologous targeting

Beumer et al. (2008) PNAS "Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases" [Pubmed]

Beumer et al. (2013) G3 (Bethesda) "Donor DNA utilization during gene targeting with zinc-finger nucleases" [Pubmed]


Cong et al. (2013) Science "Multiplex genome engineering using CRISPR/Cas systems" [Pubmed]

Mali et al. (2013) Science "RNA-guided human genome engineering via Cas9" [Pubmed]

Jiang et al. (2013) Nat Biotechnol "RNA-guided editing of bacterial genomes using CRISPR-Cas systems" [Pubmed]

Cho et al. (2013) Nat Biotechnol "Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease" [Pubmed]

Jinek et al. (2013) Elife "RNA-programmed genome editing in human cells" [Pubmed]

Wang et al. (2013) Cell "One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering" [Pubmed]

Fu et al. (2013) Nat Biotechnol "High frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells" [Pubmed]


Hwang et al. (2013) Nat Biotechnol "Efficient genome editing in zebrafish using a CRISPR-Cas system" [Pubmed]

Chang et al. (2013) Cell Res "Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos" [Pubmed]

Xiao et al. (2013) Nucleic Acids Res "Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish" [Pubmed]


Dahlem et al. (2012) PLoS Genet "Simple methods for generating and detecting locus-specific mutations induced with TALENs in the zebrafish genome" [Pubmed]

Bacterial CRISPR

Barrangou et al. (2007) Science "CRISPR provides acquired resistance against viruses in prokaryotes" [Pubmed]

Brouns et al. (2008) Science "Small CRISPR RNAs guide antiviral defense in prokaryotes" [Pubmed]

Westra et al. (2012) Annu Rev Genet "The CRISPRs, they are a-changin': how prokaryotes generate adaptive immunity" [Pubmed]

Jinek et al. (2012) Science "A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity" [Pubmed]


Sander et al. (2010) Nucleic Acids Res "ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool" [Pubmed]

Lee et al. (2013) PNAS "RNA-protein analysis using a conditional CRISPR nuclease" [Pubmed]

DiCarlo et al. (2013) Nucleic Acids Res "Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems" [Pubmed]

Qi et al. (2013) Cell "Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression" [Pubmed]