Gratz et al. (2013) Genetics "Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease" [Pubmed]

Bassett et al. (2013) Cell Reports "Highly efficient targeted mutagenesis of Drosophila with the CRISPR/Cas9 system" [Pubmed]

Yu, Ren et al. (2013) Genetics "Highly efficient genome modifications mediated by CRISPR/Cas9 in Drosophila" [Pubmed]

Kondo and Ueda. (2013) Genetics "Highly improved gene targeting by germline-specific Cas9 expression in Drosophila" [Pubmed]

Sebo et al. (2013) Fly "A simplified and efficient germline-specific CRISPR/Cas9 system for Drosophila genomic engineering" [Pubmed]

Ren et al. (2013) PNAS "Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9" [Pubmed]

Bassett et al. (2013) Biology Open "Mutagenesis and homologous recombination in Drosophila cell lines using CRISPR/Cas9" [Pubmed]

Bassett AR and Liu JL. (2013). CRISPR/Cas9 and genome editing in Drosophila. Journal of Genetics and Genomics [Epub ahead of print 18 Dec 2013][doi:10.1016/j.jgg.2013.12.004][POSTER: Timeline of CRISPR Research]

Homologous targeting

Beumer et al. (2008) PNAS "Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases" [Pubmed]

Beumer et al. (2013) G3 (Bethesda) "Donor DNA utilization during gene targeting with zinc-finger nucleases" [Pubmed]


Cong et al. (2013) Science "Multiplex genome engineering using CRISPR/Cas systems" [Pubmed]

Mali et al. (2013) Science "RNA-guided human genome engineering via Cas9" [Pubmed]

Jiang et al. (2013) Nat Biotechnol "RNA-guided editing of bacterial genomes using CRISPR-Cas systems" [Pubmed]

Cho et al. (2013) Nat Biotechnol "Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease" [Pubmed]

Jinek et al. (2013) Elife "RNA-programmed genome editing in human cells" [Pubmed]

Wang et al. (2013) Cell "One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering" [Pubmed]

Fu et al. (2013) Nat Biotechnol "High frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells" [Pubmed]


Hwang et al. (2013) Nat Biotechnol "Efficient genome editing in zebrafish using a CRISPR-Cas system" [Pubmed]

Chang et al. (2013) Cell Res "Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos" [Pubmed]

Xiao et al. (2013) Nucleic Acids Res "Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish" [Pubmed]


Dahlem et al. (2012) PLoS Genet "Simple methods for generating and detecting locus-specific mutations induced with TALENs in the zebrafish genome" [Pubmed]

Bacterial CRISPR

Barrangou et al. (2007) Science "CRISPR provides acquired resistance against viruses in prokaryotes" [Pubmed]

Brouns et al. (2008) Science "Small CRISPR RNAs guide antiviral defense in prokaryotes" [Pubmed]

Westra et al. (2012) Annu Rev Genet "The CRISPRs, they are a-changin': how prokaryotes generate adaptive immunity" [Pubmed]

Jinek et al. (2012) Science "A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity" [Pubmed]


Sander et al. (2010) Nucleic Acids Res "ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool" [Pubmed]

Lee et al. (2013) PNAS "RNA-protein analysis using a conditional CRISPR nuclease" [Pubmed]

DiCarlo et al. (2013) Nucleic Acids Res "Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems" [Pubmed]

Qi et al. (2013) Cell "Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression" [Pubmed]