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Encoding information in neural circuits

GCaMP expression in the somatosensory cortex (green) and PV+ interneurons (red).

Although we know approximately how sensory input is routed through different brain areas, each extracting distinct aspects of the percept, the neuronal language used to represent sensory experiences and the mechanisms whereby these experiences are stored in memory remain elusive.

Our aim

Our group tries to unravel the neural coding strategies employed in the representation of sensory stimuli and memory storage. We combine electrophysiological recordings with single- and multi-photon imaging and stimulation to monitor and manipulate complex neuronal activity during behaviour in mice. Our ultimate aim is to discover fundamental neural coding principles underlying perception and memory. 

Ongoing Projects

Our current research is broadly focused on three projects:

  1. Role of interneurons in somatosensory perception.
    We study how different types of inhibitory interneurons are optimised for controlling neural codes.
  2. Role of hippocampus and retrosplenial cortex in associative memory.
    We study the interplay of hippocampus and sensory cortices with the retrosplenial cortex during the formation and retrieval of associative memories.
  3. Tool development.
    We develop novel approaches for recording and manipulating the function of large populations of neurons.

Core Team Members

Related research themes