Encoding information in neural circuits
Although we know approximately how sensory input is routed through different brain areas, each extracting distinct aspects of the percept, the neuronal language used to represent sensory experiences and the mechanisms whereby these experiences are stored in memory remain elusive.
Our group tries to unravel the neural coding strategies employed in the representation of sensory stimuli and memory storage. We combine electrophysiological recordings with single- and multi-photon imaging and stimulation to monitor and manipulate complex neuronal activity during behaviour in mice. Our ultimate aim is to discover fundamental neural coding principles underlying perception and memory.
Our current research is broadly focused on three projects:
Role of interneurons in somatosensory perception.
We study how different types of inhibitory interneurons are optimised for controlling neural codes.
Role of hippocampus and retrosplenial cortex in associative memory.
We study the interplay of hippocampus and sensory cortices with the retrosplenial cortex during the formation and retrieval of associative memories.
We develop novel approaches for recording and manipulating the function of large populations of neurons.
- Oct/16: Welcome Jee!
Our close collaborator and colleague, Prof Jeehyun Kwag, head of the Neural Computation Laboratory at Korea University, Seoul, returns to Oxford to join the lab for her sabbatical 2016/17.
- Oct/16: Welcome Severin!
Severin Limal joins us for graduate studies towards a D.Phil in Neuroscience. In collaboration with the King and Walker labs, he will be investigating the integration of auditory and somatosensory stimuli.
- Jun/16: Welcome Aaron!
As part of the Oxford Hotchkiss Brain Institute Summer Student Exchange Scheme, Aaron Lanz joins us from Calgary for a three month project to study synaptic plasticity rules in the retrosplenial cortex.
- May/16: Welcome Matt!
Matthew Tran from our Linc Lab collaborators in Toronto joins us for the summer to learn advanced imaging methods.
- May/16: Welcome Karyna!
Biomedical Science student Karyna Mishchanchuk joins the lab for her FHS project. She will study synaptic plasticity in the retrosplenial cortex.
+++ October 2016 +++
+++ POSTDOC POSITION AVAILABLE +++
Work with us:
If you share our interest in the link between brain activity and behaviour, get excited by neural circuits, and have a strong background in two-photon imaging and neurobiology, come join us! We currently have a post-doc position available on an exciting project aimed at using holographic 2-photon stimulation to test the necessity and sufficiency of specific neural codes in sensory perception. Apply now via DPAG Current Vacancies or Email us to find out more.
Study with us:
Do you love neural circuits and would like to play with lasers and amplifiers? Join us for a FHS, MSc or DPhil project! Click here to Email us and get in touch to find out more about available projects and funding. We are affiliated with lots of Oxford's Doctoral Training Programmes, including the Wellcome Trust DPhil / MSc in Neuroscience, OXION , Systems Biology and the Interdisciplinary Bioscience DTP.Find out more
Collaborators, Project Students and Visitors
We are lucky to be able to work with many inspiring researchers that are not core team members. With them, we share expertise, resources, reagents, personnel, and, occasionally, conference accommodation...Find out more