Encoding information in neural circuits.
Although we know approximately how sensory input is routed through different brain areas, each extracting distinct aspects of the percept, the neuronal language used to represent sensory experiences and the mechanisms whereby these experiences are stored in memory remain elusive.
Our group tries to unravel the neural coding strategies employed in the representation of sensory stimuli and memory storage. We combine electrophysiological recordings with single- and multi-photon imaging and stimulation to monitor and manipulate complex neuronal activity during behaviour in mice. Our ultimate aim is to discover fundamental neural coding principles underlying perception and memory.
Our current research is broadly focused on three projects:
Role of interneurons in somatosensory perception.
We study how different types of inhibitory interneurons are optimised for controlling neural codes.
Role of hippocampus and retrosplenial cortex in associative memory.
We study the interplay of hippocampus and sensory cortices with the retrosplenial cortex during the formation and retrieval of associative memories.
We develop novel approaches for recording and manipulating the function of large populations of neurons.
- Dec/16: Welcome Mariangela!
Following her successful D.Phil defence, Mariangela Panniello joins us for post-doctoral work on sensory information processing using multiplexed 2-photon imaging.
- Dec/16: New collaboration.
We started working with sciNote to adapt their electronic lab notebook to our electrophysiology-imaging-behaviour workflow and thereby improve and simplify traceability of data for deposition in open access archives.
- Nov/16: Congrats Aaron!
Aaron wins First Prize at the University of Calgary Neuroscience Student Association Research Night 2016 with his work on synaptic plasticity in the retrosplenial cortex.
- Oct/16: Welcome Jee!
Our close collaborator and colleague, Prof Jeehyun Kwag, head of the Neural Computation Laboratory at Korea University, Seoul, returns to Oxford to join the lab for her sabbatical 2016/17.
Work with us:
If you share our interest in the link between brain activity and behaviour, get excited by neural circuits, and have a strong background in two-photon imaging and neurobiology, come join us! We currently have a post-doc position available on an exciting project aimed at using holographic two-photon stimulation to test the necessity and sufficiency of specific neural codes in sensory perception. Email us to find out more.
Study with us:
Do you love neural circuits and would like to play with lasers and amplifiers? Join us for a FHS, MSc or DPhil project! Click here to Email us and get in touch to find out more about available projects and funding. We are affiliated with lots of Oxford's Doctoral Training Programmes, including the Wellcome Trust DPhil / MSc in Neuroscience, OXION , Systems Biology and the Interdisciplinary Bioscience DTP.More news
Collaborators, Project Students and Visitors
We are lucky to be able to work with many inspiring researchers that are not core team members. With them, we share expertise, resources, reagents, personnel, and, occasionally, conference accommodation...More news