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DIscovery of novel gene mutations in cerebellar ataxia
Elucidating key pathways affected in cerebellar disorders
Differentiation of human iPSC-derived cerebellar neurons and organoids
Understanding Cerebellar Development and Disease
Welcome to the Becker Group!
We are interested in discovering the genes and biological mechanisms that regulate the development of the cerebellum and in exploring how the impairment of these mechanisms leads to cerebellar diseases.
The cerebellum is well-known as the primary centre of motor coordination and learning in the central nervous system. However, increasing evidence suggests a much wider function for the "little brain", including in higher cognitive functions such as language, emotion and social reward processing. We understand surprisingly little about the molecular processes that underlie the formation of the cerebellum and that, when disrupted, lead to disease. The goal of our research is to provide fundamental insights into the genetic, molecular and cellular mechanisms that govern the development and different diseases of the cerebellum.
We have recently identified the first dominant gene mutations in Spinocerebellar Ataxia type 41 (SCA41) and Spinocerebellar Ataxia type 44 (SCA44), and our ongoing work focuses on elucidating the role of mGluR1-TRPC3 signaling in cerebellar ataxia.
Interestingly, the cerebellum has emerged as one of the key brain areas affected in autism spectrum disorder. However, the molecular mechanisms linking cerebellar function to autism remain largely unknown. We are addressing this important question by investigating the role of autism genes in the development and function of the cerebellum by integrating experimental developmental neurobiology and computational analyses. Our recent work has shown that a subset of autism genes is highly enriched in developing Purkinje cells.
Our group is one of the few laboratories worldwide who have developed a robust protocol to generate cerebellar neurons and organoids from human induced pluripotent stem cells (iPSCs). This exciting technology allows us, for the first time, to study the development and function of human cerebellar neurons in the dish using available cells from healthy people as well as patients with cerebellar disorders.
Together, our work provides a more rigorous understanding of the genes and pathways behind these diseases. We hope that our findings will ultimately help to inspire improved clinical treatments.
Join the lab
We are a young, international and enthusiastic group. Enquiries from motivated and talented students and post-docs to discuss available research projects and funding possibilities are always welcome. Get in touch
Opportunities for DPhil/PhD projects in the Becker group are available through a number of graduate programmes:
Our lab is proud to be part of the fantastic in2science programme that provides research placements for students from disadvantaged backgrounds.
Esther was one of the invited keynote speakers at the Empowered Women event in April 2014 that was hosted by the Charity Wishful Smiles together with Barry Gardiner MP at the Houses of Parliament.
In the news
The use of patient stem cell-derived mini-brains to study A-T, supported by Action for A-T
From school desk to lab bench: local students take part in In2Science programme
Report on the 2nd Biennual Oxford Rare Disease Initiative Conference
Using stem cells to battle brain diseases ATLAS of Science
Mutated gene gets mice 'moonwalking' New Scientist
July 2019: Welcome to Max van Essen, who will do his DPhil in the lab supported by a clinical fellowship from the CRUK Oxford Centre
May 2019: Welcome to OXION rotation student Jodie Collingridge!
February 2019: Congratulations to Friederike for passing her DPhil viva!
January 2019: Our cerebellar differentiation paper has been voted "Best 2018 Paper" in Cerebellum
Nov/Dec 2018: Congratulations to the first batch of graduates from our lab, Dr. Maggie Wong and Dr. Liam Argent!
August 2018: We are excited to host in2science student Emma Davies for a placement in our group
May 2018: Alaa Baazaoui, MSc project student from Cologne, joins our group. Welcome!
April 2018: Welcome to DTP PhD student Elise Padbury, who is doing a joined project with Dave Carter's group at Oxford Brookes and us
January 2018: Welcome to DTP rotation student Melissa Grant-Hänni!
October 2017: Great article by Lauren on iPSC-based models of neurodegenerative diseases: promises and pitfalls in this term's issue of Phenotype
September 2017: Welcome to Mimi Prickett, who will carry out her Biochemistry Part II project in our group