Striatin plays a major role in angiotensin II-induced cardiomyocyte and cardiac hypertrophy in mice in vivo.
Cull JJ. et al, (2024), Clin Sci (Lond), 138, 573 - 597
Erratum to ‘Defining Commotio Cordis’: The American Journal of Cardiology Volume 124, Issue 10, 15 November 2019, Pages 1649-1650 (The American Journal of Cardiology (2019) 124(10) (1649–1650), (S0002914919309415), (10.1016/j.amjcard.2019.08.006))
Maron BJ. et al, (2023), American Journal of Cardiology, 193
Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice.
Alharbi HO. et al, (2022), Clin Sci (Lond), 136, 1661 - 1681
PKN2 deficiency leads both to prenatal 'congenital' cardiomyopathy and defective angiotensin II stress responses.
Marshall JJT. et al, (2022), Biochem J, 479, 1467 - 1486
Of Mouse and Man: Cross-Species Characterization of Hypertensive Cardiac Remodeling.
Cooper STE. et al, (2022), Int J Mol Sci, 23
BS8 RAF ‘paradox breaker’ PLX8394 activates ERK1/2 VIA craf, with no effect on angii-induced cardiac remodelling in mice
Cooper S. et al, (2022), Basic science
Characterisation of hypertensive heart disease: pathological insights from a sudden cardiac death cohort to inform clinical practice.
Westaby JD. et al, (2022), J Hum Hypertens, 36, 246 - 253
Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo.
Clerk A. et al, (2022), Biochem J, 479, 401 - 424
The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension.
Meijles DN. et al, (2021), Clin Sci (Lond), 135, 1631 - 1647
The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α1-adrenergic receptors.
Meijles DN. et al, (2021), Biochem J, 478, 2059 - 2079
BS33 The RAF ‘paradox breaker’ inhibitor, PLX8394, activates ERK1/2 in endothelial cells and promotes cardiac remodelling
Cooper S. et al, (2021), Basic science
The role of endocarditis in sudden cardiac death: highlighting the value of the autopsy, pathological features and cardiac complications
Cooper STE. et al, (2021), Cardiovascular Pathology, 50
Redox Regulation of Cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) Controls p38-MAPK (Mitogen-Activated Protein Kinase) and Orchestrates Cardiac Remodeling to Hypertension.
Meijles DN. et al, (2020), Hypertension, 76, 1208 - 1218
Insights from examination of hearts from adults dying suddenly to the understanding of congenital cardiac malformations.
Westaby JD. et al, (2020), Clin Anat, 33, 394 - 404
Inhibition of Egfr Signalling Promotes Maladaptive Cardiac Remodelling in Hypertensive Heart Disease
Cooper S. et al, (2020), CIRCULATION, 142
A Lethal Blow to the Chest as an Underdiagnosed Cause of Sudden Death in United Kingdom Sports (Football, Cricket, Rugby).
Cooper S. et al, (2019), Am J Cardiol, 124, 808 - 811