Role of the Lymphatics in Cardiac Disease.
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Striatin plays a major role in angiotensin II-induced cardiomyocyte and cardiac hypertrophy in micein vivo
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Erratum to ‘Defining Commotio Cordis’: The American Journal of Cardiology Volume 124, Issue 10, 15 November 2019, Pages 1649-1650 (The American Journal of Cardiology (2019) 124(10) (1649–1650), (S0002914919309415), (10.1016/j.amjcard.2019.08.006))
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Abstract P3113: RAF 'Paradox Breaker' Inhibitor, PLX8394, Enhances Inflammation And Apoptosis In Murine Hypertension In Vivo
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Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice.
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PKN2 deficiency leads both to prenatal 'congenital' cardiomyopathy and defective angiotensin II stress responses.
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Of Mouse and Man: Cross-Species Characterization of Hypertensive Cardiac Remodeling.
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BS8 RAF ‘paradox breaker’ PLX8394 activates ERK1/2 VIA craf, with no effect on angii-induced cardiac remodelling in mice
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Cooper S. et al, (2022), Basic science
Characterisation of hypertensive heart disease: pathological insights from a sudden cardiac death cohort to inform clinical practice.
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Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo.
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The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension.
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The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α1-adrenergic receptors.
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BS33 The RAF ‘paradox breaker’ inhibitor, PLX8394, activates ERK1/2 in endothelial cells and promotes cardiac remodelling
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Cooper S. et al, (2021), Basic science
The role of endocarditis in sudden cardiac death: highlighting the value of the autopsy, pathological features and cardiac complications
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Cooper STE. et al, (2021), Cardiovascular Pathology, 50
Redox Regulation of Cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) Controls p38-MAPK (Mitogen-Activated Protein Kinase) and Orchestrates Cardiac Remodeling to Hypertension.
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Meijles DN. et al, (2020), Hypertension, 76, 1208 - 1218
Insights from examination of hearts from adults dying suddenly to the understanding of congenital cardiac malformations.
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Westaby JD. et al, (2020), Clin Anat, 33, 394 - 404
Inhibition of Egfr Signalling Promotes Maladaptive Cardiac Remodelling in Hypertensive Heart Disease
Conference paper
Cooper S. et al, (2020), CIRCULATION, 142
Defining Commotio Cordis.
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Maron BJ. and Sheppard CS., (2019), Am J Cardiol, 124, 1649 - 1650
A Lethal Blow to the Chest as an Underdiagnosed Cause of Sudden Death in United Kingdom Sports (Football, Cricket, Rugby).
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