Several studies have demonstrated that electrical activation of the peripheral vestibular system can evoke field potential, multi-unit neuronal activity and acetylcholine release in the hippocampus (HPC). However, no study to date has employed the immediate early gene protein, c-Fos, to investigate the distribution of activation of cells in the HPC following electrical stimulation of the vestibular system. We found that vestibular stimulation increased the number of animals expressing c-Fos in the dorsal HPC compared to sham control rats (P ≤ 0.02), but not in the ventral HPC. c-Fos was also expressed in an increased number of animals in the dorsal dentate gyrus (DG) compared to sham control rats (P ≤ 0.0001), and to a lesser extent in the ventral DG (P ≤ 0.006). The results of this study show that activation of the vestibular system results in a differential increase in the expression of c-Fos across different regions of the HPC.
Journal article
2018-06-11T00:00:00+00:00
677
60 - 64
4
Electrical stimulation, Hippocampus, Vestibular system, c-Fos, Animals, Electric Stimulation, Hippocampus, Neural Pathways, Neurons, Proto-Oncogene Proteins c-fos, Rats, Wistar, Vestibule, Labyrinth