Ion channels and G-protein-coupled receptors (GPCRs) play a fundamental role in cancer progression by influencing Ca(2+) influx and signaling pathways in transformed cells. Transformed cells thrive in a hostile environment that is characterized by extracellular acidosis that promotes the pathological phenotype. The pathway(s) by which extracellular protons achieve this remain unclear. Here, a role for proton-sensing ion channels and GPCRs as mediators of the effects of extracellular protons in cancer cells is discussed.
Journal article
2011-08-01T00:00:00+00:00
26
252 - 265
13
Animals, Calcium, Calcium Signaling, Disease Progression, Humans, Hydrogen, Ion Channels, Neoplasms, Protons, Receptors, G-Protein-Coupled