The electrophysiological relevance of interstitial nonmyocytes for cardiac electrophysiology arises from their abundant direct and indirect interactions with cardiac myocytes. This review defines the interstitium, explores biophysical and biochemical mechanisms of interactions between interstitial components and cardiac myocytes, illustrates consequences of these interactions for heart rhythm, and identifies targets for further research in this area.
Journal article
2026-04-01T00:00:00+00:00
330
C943 - C953
arrhythmia, fibrosis, heart, heterocellular coupling, interstitium, Humans, Arrhythmias, Cardiac, Animals, Myocytes, Cardiac, Action Potentials, Cell Communication, Heart Rate