3D hybrid-shot spiral sequence for hyperpolarized 13C imaging.

Tyler A., Lau JYC., Ball V., Timm KN., Zhou T., Tyler DJ., Miller JJ.

PURPOSE: Hyperpolarized imaging experiments have conflicting requirements of high spatial, temporal, and spectral resolution. Spectral-spatial RF excitation has been shown to form an attractive magnetization-efficient method for hyperpolarized imaging, but the optimum readout strategy is not yet known. METHODS: In this work, we propose a novel 3D hybrid-shot spiral sequence which features two constant density regions that permit the retrospective reconstruction of either high spatial or high temporal resolution images post hoc, (adaptive spatiotemporal imaging) allowing greater flexibility in acquisition and reconstruction. RESULTS: We have implemented this sequence, both via simulation and on a preclinical scanner, to demonstrate its feasibility, in both a 1H phantom and with hyperpolarized 13C pyruvate in vivo. CONCLUSIONS: This sequence forms an attractive method for acquiring hyperpolarized imaging datasets, providing adaptive spatiotemporal imaging to ameliorate the conflict of spatial and temporal resolution, with significant potential for clinical translation.

DOI

10.1002/mrm.28462

Type

Journal article

Publication Date

2021-02-01T00:00:00+00:00

Volume

85

Pages

790 - 801

Total pages

11

Keywords

DNP, hyperpolarized 13C, metabolic imaging, pulse sequence design, spectral-spatial RF, spiral imaging, Carbon Isotopes, Echo-Planar Imaging, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Phantoms, Imaging, Pyruvic Acid, Retrospective Studies

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