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The perirhinal cortex (PRH) is considered a crucial cortical area for familiarity memory and electrophysiological studies have reported the presence of visual familiarity encoding neurons in PRH. However, recent evidence has questioned the existence of these neurons. Here, we used a visual task in which head-restrained mice were passively exposed to oriented gratings or natural images. Evoked potentials and single-unit recordings showed evoked responses to novelty in V1 under some conditions. However, the PRH showed no response modulation with respect to familiarity under a variety of different conditions or retention delays. These results indicate that the PRH does not contribute to familiarity/novelty encoding using passively exposed visual stimuli.

Original publication

DOI

10.1016/j.neuroscience.2018.10.020

Type

Journal article

Journal

Neuroscience

Publication Date

01/12/2018

Volume

394

Pages

23 - 29

Keywords

ensemble recordings, medial temporal lobe, memory, visual evoked potentials, Animals, Discrimination (Psychology), Evoked Potentials, Visual, Female, Male, Mice, Inbred C57BL, Neurons, Pattern Recognition, Visual, Perirhinal Cortex, Photic Stimulation, Recognition (Psychology), Visual Cortex