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Obesity is a worldwide public health concern yet no safe therapies are currently available. The activity of sympathetic neurons is necessary and sufficient for fat mass reduction, via norepinephrine (NE) signaling. Macrophage accumulation in the adipose tissue is thought to play the central role in the onset of obesity, yet their relation to NE has been controversial. We have identified a population of sympathetic neuron-associated macrophages (SAMs) that control obesity via the uptake and clearing of NE. Here we focus on the neuro-immune regulation of obesity by discussing the genetic, cellular and functional signatures of SAMs vis-a-vis adipose tissue macrophages (ATMs).

Original publication

DOI

10.1016/j.cellimm.2018.04.014

Type

Journal article

Journal

Cell Immunol

Publication Date

08/2018

Volume

330

Pages

183 - 187

Keywords

Adipose tissue, Macrophages, Neuro-immune interactions, Obesity, Sympathetic neuron-associated macrophages, Adipocytes, Adipose Tissue, Animals, Homeostasis, Humans, Macrophages, Neurons, Norepinephrine, Obesity, Sympathetic Nervous System