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The promise of nucleic acid based oligonucleotides as effective genetic therapies has been held back by their low bioavailability and poor cellular uptake to target tissues upon systemic administration. One such strategy to improve upon delivery is the use of short cell-penetrating peptides (CPPs) that can be either directly attached to their cargo through covalent linkages or through the formation of noncovalent nanoparticle complexes that can facilitate cellular uptake. In this review, we will highlight recent proof-of-principle studies that have utilized both of these strategies to improve nucleic acid delivery and discuss the prospects for translation of this approach for clinical application.

Original publication

DOI

10.3390/biomedicines6020051

Type

Journal article

Journal

Biomedicines

Publication Date

05/05/2018

Volume

6

Keywords

antisense oligonucleotides, cell-penetrating peptides, delivery