Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we will assume that you are happy to receive all cookies and you will not see this message again. Click 'Find out more' for information on how to change your cookie settings.

In this paper, we present a novel approach to quantify the spatio-temporal organization of electrical activation during human ventricular fibrillation (VF). We propose three different methods based on correlation analysis, graph theoretical measures and hierarchical clustering. Using the proposed approach, we quantified the level of spatio-temporal organization during three episodes of VF in ten patients, recorded using multi-electrode epicardial recordings with 30 s coronary perfusion, 150 s global myocardial ischaemia and 30 s reflow. Our findings show a steady decline in spatio-temporal organization from the onset of VF with coronary perfusion. We observed transient increases in spatio-temporal organization during global myocardial ischaemia. However, the decline in spatio-temporal organization continued during reflow. Our results were consistent across all patients, and were consistent with the numbers of phase singularities. Our findings show that the complex spatio-temporal patterns can be studied using complex network analysis.

Original publication

DOI

10.1007/s10439-018-2007-9

Type

Journal article

Journal

Ann Biomed Eng

Publication Date

06/2018

Volume

46

Pages

864 - 876

Keywords

Complex network analysis, Cross-correlation, Global myocardial ischaemia, Hierarchical clustering, Spatio-temporal systems, Electrophysiologic Techniques, Cardiac, Female, Humans, Male, Myocardial Ischemia, Pericardium, Ventricular Fibrillation