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Here we seek to establish whether there are activities in the human pallidum that may predict a specific aspect of performance, timing. When recording from two patients with Parkinson's disease and primary generalised dystonia following functional neurosurgery we found that the amplitude of oscillatory pallidal activity occurring prior to the completion of a bimanual timing task was strongly correlated with eventual task duration. The frequency of this oscillatory activity was around 25 Hz. We conclude that the human pallidum may be involved in the prediction of movement timings and that such internal estimates may be reflected in amplitude modulation of oscillatory activity around 25 Hz.


Journal article


Neurosci Lett

Publication Date





188 - 192


Beta Rhythm, Electrodes, Implanted, Electromyography, Evoked Potentials, Motor, Female, Fourier Analysis, Functional Laterality, Globus Pallidus, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Movement, Parkinson Disease, Psychomotor Performance, Reaction Time, Subthalamic Nucleus