Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we will assume that you are happy to receive all cookies and you will not see this message again. Click 'Find out more' for information on how to change your cookie settings.

Synaptic plasticity, a key process for memory formation, manifests itself across different time scales ranging from a few seconds for plasticity induction up to hours or even years for consolidation and memory retention. We developed a three-layered model of synaptic consolidation that accounts for data across a large range of experimental conditions. Consolidation occurs in the model through the interaction of the synaptic efficacy with a scaffolding variable by a read-write process mediated by a tagging-related variable. Plasticity-inducing stimuli modify the efficacy, but the state of tag and scaffold can only change if a write protection mechanism is overcome. Our model makes a link from depotentiation protocols in vitro to behavioral results regarding the influence of novelty on inhibitory avoidance memory in rats.

Original publication

DOI

10.1523/JNEUROSCI.3989-14.2015

Type

Journal article

Journal

J Neurosci

Publication Date

21/01/2015

Volume

35

Pages

1319 - 1334

Keywords

consolidation, modeling, synaptic tagging, Action Potentials, Animals, Computer Simulation, Models, Neurological, Neuronal Plasticity, Neurons, Synapses