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Notch signalling is essential for animal development. It integrates multiple pathways controlling cell fate and specification. Here we report the genetic characterization of Gliolectin, presumably a lectin, a cytoplasmic protein, significantly enriched in Golgi bodies. Its expression overlaps with regions where Notch is activated. Loss of gliolectin function results in ectopic veins, while gain of its function causes loss of wing veins. It positively regulates Enhancer of split mβ, a target of Notch signalling. These observations suggest that it is a positive regulator of Notch signalling during wing development in Drosophila.

Original publication




Journal article


Int J Dev Biol

Publication Date





187 - 194


Animals, Animals, Genetically Modified, Drosophila Proteins, Drosophila melanogaster, Gene Expression Regulation, Developmental, Golgi Apparatus, Imaginal Discs, In Situ Hybridization, Lectins, Luminescent Proteins, Nerve Tissue Proteins, RNA Interference, Receptors, Notch, Signal Transduction, Wings, Animal