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Notch signalling is essential for animal development. It integrates multiple pathways controlling cell fate and specification. Here we report the genetic characterization of Gliolectin, presumably a lectin, a cytoplasmic protein, significantly enriched in Golgi bodies. Its expression overlaps with regions where Notch is activated. Loss of gliolectin function results in ectopic veins, while gain of its function causes loss of wing veins. It positively regulates Enhancer of split mβ, a target of Notch signalling. These observations suggest that it is a positive regulator of Notch signalling during wing development in Drosophila.

Original publication

DOI

10.1387/ijdb.140190LS

Type

Journal article

Journal

Int J Dev Biol

Publication Date

2015

Volume

59

Pages

187 - 194

Keywords

Animals, Animals, Genetically Modified, Drosophila Proteins, Drosophila melanogaster, Gene Expression Regulation, Developmental, Golgi Apparatus, Imaginal Discs, In Situ Hybridization, Lectins, Luminescent Proteins, Nerve Tissue Proteins, RNA Interference, Receptors, Notch, Signal Transduction, Wings, Animal