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Over the last decades, a large number of experimental models have been developed to explore the mechanisms underlying neurodegenerative disorders. Invertebrate models of neurodegeneration, such as the fruit fly Drosophila melanogaster and the nematode Caenorhabtidis elegans, have emerged as successful complementary systems to mammalian models, facilitating identification of relevant pathways and novel diseaseassociated genes. These organisms provide reliable systems for identifying genetic modifiers of neuropathologies and the interesting possibility of screening and testing potential drugs for treatments to prevent and/or alleviate disease symptoms. This chapter will focus on the main experimental strategies used in Drosophila melanogaster and Caenorhabtidis elegans to study neurodegeneration. Insights from forward genetic approaches, transgenic models of human neurodegenerative disorders and studies of fly/worm homologs of human disease genes will be presented. The value of using invertebrate models for the study of neurodegeneration will be discussed, highlighting advantages and limitations associated with these studies.

Original publication

DOI

10.2174/97816080599281150101

Type

Chapter

Book title

Young Perspectives for Old Diseases

Publisher

Bentham Science Publishers