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Chronic HBV infection remains an important public health problem and currently licensed therapies rarely prevent complications of viral persistence. Silencing HBV gene expression using gene therapy, particularly with exogenous activators of RNAi, holds promise for developing an HBV gene therapy. However, immune stimulation, off-targeting effects and inefficient delivery of RNAi activators remain problematic. Several new approaches have recently been employed to address these issues. Chemical modifications to anti-HBV synthetic siRNAs have been investigated and a variety of vectors are being developed for delivery of RNAi effectors. In this article, we review the potential utility of gene therapy for treating HBV infection.

Original publication

DOI

10.2217/fmb.13.87

Type

Journal article

Journal

Future Microbiol

Publication Date

11/2013

Volume

8

Pages

1489 - 1504

Keywords

Animals, Genetic Therapy, Hepatitis B, Hepatitis B virus, Humans, RNA Interference, RNA, Small Interfering