Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we will assume that you are happy to receive all cookies and you will not see this message again. Click 'Find out more' for information on how to change your cookie settings.

Heterogeneous anabolic capacity in cell populations can trigger a phenomenon known as cell competition, through which less active cells are eliminated. Cell competition has been induced experimentally in stem/precursor cell populations in insects and mammals and takes place endogenously in early mouse embryonic cells. Here, we show that cell competition can be efficiently induced in mouse cardiomyocytes by mosaic overexpression of Myc during both gestation and adult life. The expansion of the Myc-overexpressing cardiomyocyte population is driven by the elimination of wild-type cardiomyocytes. Importantly, this cardiomyocyte replacement is phenotypically silent and does not affect heart anatomy or function. These results show that the capacity for cell competition in mammals is not restricted to stem cell populations and suggest that stimulated cell competition has potential as a cardiomyocyte-replacement strategy.

Original publication

DOI

10.1016/j.celrep.2014.08.005

Type

Journal article

Journal

Cell Rep

Publication Date

25/09/2014

Volume

8

Pages

1741 - 1751

Keywords

Animals, Apoptosis, Embryo, Mammalian, Female, Green Fluorescent Proteins, Heart, Homeodomain Proteins, Integrases, LIM-Homeodomain Proteins, Male, Mice, Myocytes, Cardiac, Phenotype, Proto-Oncogene Proteins c-myc, Recombination, Genetic, Stem Cells, Transcription Factors