Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we will assume that you are happy to receive all cookies and you will not see this message again. Click 'Find out more' for information on how to change your cookie settings.

Comparative analyses of eukaryotic genomes are providing insights into the mode and tempo of domain family evolution. Gene duplication, the source of family expansion, far exceeds the rate of emergence of domains from non-coding sequence, and the rate of recruitment of domains into novel architectures. Domain families that appear to be restricted to certain lineages are likely to be the result of gene duplication, coupled with rapid sequence diversification. If such families are evidence of past adaptation, then their functions must relate to the underlying mechanism of selection: competition among organisms.

Type

Journal article

Journal

Curr Opin Genet Dev

Publication Date

12/2003

Volume

13

Pages

623 - 628

Keywords

Animals, Eukaryotic Cells, Evolution, Molecular, Gene Duplication, Genome, Humans, Protein Structure, Tertiary, Selection, Genetic