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The history of the constitution perspective in medical care dates back thousands of years and extends from the East to the West. Among the various forms of constitutional medicine, Sasang constitutional medicine (SCM) is a holistic, tailored medical approach that is based on a well-structured theoretical system that includes physiopathological disciplines. Scientific evidence has demonstrated that SCM typology has a constitution-specific basis in anthropometrics, physiological characteristics, disease vulnerability, and genetic origins. Furthermore, the recent rise of systems biology, which requires whole body modeling, uses a state-of-the-art approach in interpreting the holistic spirit of Oriental medicine. This article aims to provide an overview of the recent achievements in SCM research and to discuss how the concept of balance in SCM may contribute to the development of large scale modeling in systems biology.

Original publication




Journal article


Prog Biophys Mol Biol

Publication Date





76 - 80


Biology, Constitutional, MedicineSasang, MedicineSystems, Oriental, Body Constitution, Computer Simulation, Forecasting, Holistic Health, Models, Biological, Patient-Specific Modeling, Systems Biology