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The neurodegenerative disorder amyotrophic lateral sclerosis may render patients unable to speak or write, so that objective assessment of cognitive impairment, which is commonly of a dysexecutive nature, is challenging. There is therefore a need to develop other methods of assessment that utilize other relatively unaffected motor systems. In this proof-of-principle study a novel eye-tracking version of the trail-making test was compared with performance on the standard written version in a group of healthy volunteers. There was good correlation for speed between both versions of Part B (R(2)=0.73), suggesting that this is a viable method to objectively assess cognitive impairment in disorders where patients are unable to speak or write.

Original publication

DOI

10.1371/journal.pone.0084061

Type

Journal article

Journal

PLoS One

Publication Date

2013

Volume

8

Keywords

Adult, Amyotrophic Lateral Sclerosis, Eye Movements, Female, Healthy Volunteers, Humans, Male, Middle Aged, Trail Making Test, Young Adult