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Measurement of cerebrovascular reactivity (CVR) can give valuable information about existing pathology and the risk of adverse events, such as stroke. A common method of obtaining regional CVR values is by measuring the blood flow response to carbon dioxide (CO 2)-enriched air using arterial spin labeling (ASL) or blood oxygen level-dependent (BOLD) imaging. Recently, several studies have used carbogen gas (containing only CO 2 and oxygen) as an alternative stimulus. A direct comparison was performed between CVR values acquired by ASL and BOLD imaging using stimuli of (1) 5% CO 2 in air and (2) 5% CO 2 in oxygen (carbogen-5). Although BOLD and ASL CVR values are shown to be correlated for CO 2 in air (mean response 0.11±0.03% BOLD, 4.46±1.80% ASL, n=16 hemispheres), this correlation disappears during a carbogen stimulus (0.36±0.06% BOLD, 4.97±1.30% ASL). It is concluded that BOLD imaging should generally not be used in conjunction with a carbogen stimulus when measuring CVR, and that care must be taken when interpreting CVR as measured by ASL, as values obtained from different stimuli (CO 2 in air versus carbogen) are not directly comparable. © 2013 ISCBFM.

Original publication

DOI

10.1038/jcbfm.2013.131

Type

Journal article

Journal

Journal of Cerebral Blood Flow and Metabolism

Publication Date

01/11/2013

Volume

33

Pages

1799 - 1805