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During development of the mammalian cerebral cortex, radial glial cells (RGCs) generate layer-specific subtypes of excitatory neurons in a defined temporal sequence, in which lower-layer neurons are formed before upper-layer neurons. It has been proposed that neuronal subtype fate is determined by birthdate through progressive restriction of the neurogenic potential of a common RGC progenitor. Here, we demonstrate that the murine cerebral cortex contains RGC sublineages with distinct fate potentials. Using in vivo genetic fate mapping and in vitro clonal analysis, we identified an RGC lineage that is intrinsically specified to generate only upper-layer neurons, independently of niche and birthdate. Because upper cortical layers were expanded during primate evolution, amplification of this RGC pool may have facilitated human brain evolution.

Original publication

DOI

10.1126/science.1223616

Type

Journal article

Journal

Science

Publication Date

10/08/2012

Volume

337

Pages

746 - 749

Keywords

Animals, Cell Lineage, Cell Proliferation, Cells, Cultured, Cerebral Cortex, Homeodomain Proteins, Mice, Neural Stem Cells, Neurogenesis, Neuroglia, Neurons, Recombination, Genetic