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Acetylcholinesterase-rich neurons (AChERN) are a particular group of pyramidal neurons, displaying a specific laminar and ontogenetic pattern in the cerebral cortex of human and nonhuman primates. Using histochemistry and morphometrical methods, we have found a layer 3 magnopyramidal AChERN left-right size asymmetry restricted to Brodmann's area 45, a component of Broca's language area. This structural feature could be related to functional lateralization associated to syntactic processing and phonological working memory, and is consistent with a non-cholinergic role of AChE possibly linked to neuroplastic processes in the human neocortex.

Original publication

DOI

10.1016/j.brainres.2004.08.050

Type

Journal article

Journal

Brain Res

Publication Date

12/11/2004

Volume

1026

Pages

313 - 316

Keywords

Acetylcholinesterase, Aged, Cell Count, Cell Size, Female, Frontal Lobe, Functional Laterality, Humans, Male, Postmortem Changes, Pyramidal Cells