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It is generally accepted that human Alzheimer's disease (AD) neuropathology markers are completely absent in rodent brains. We report here that an aged wild-type South American rodent, Octodon degu, expresses neuronal beta-amyloid precursor protein (beta-APP695) displaying both intracellular and extracellular deposits of amyloid-beta-peptide (Abeta), intracellular accumulations of tau-protein and ubiquitin, a strong astrocytic response and acetylcholinesterase (AChE)-rich pyramidal neurons. The high amino acid homology (97.5%) between deguAbeta and humanAbeta sequences is probably a major factor in the appearance of AD markers in this aged rodent. Our results indicate that aged O. degu constitutes the first wild-type rodent model for neurodegenerative processes associated to AD.

Original publication

DOI

10.1016/j.neurobiolaging.2004.09.016

Type

Journal article

Journal

Neurobiol Aging

Publication Date

07/2005

Volume

26

Pages

1023 - 1028

Keywords

Acetylcholinesterase, Aging, Alzheimer Disease, Amino Acid Sequence, Amyloid beta-Peptides, Animals, Astrocytes, Blotting, Northern, Brain, Disease Models, Animal, Gene Expression Regulation, Glial Fibrillary Acidic Protein, Humans, Immunohistochemistry, Neurons, Octodon, RNA, Messenger, Rats, Reverse Transcriptase Polymerase Chain Reaction, Ubiquitin, tau Proteins