Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we will assume that you are happy to receive all cookies and you will not see this message again. Click 'Find out more' for information on how to change your cookie settings.

It is generally accepted that human Alzheimer's disease (AD) neuropathology markers are completely absent in rodent brains. We report here that an aged wild-type South American rodent, Octodon degu, expresses neuronal beta-amyloid precursor protein (beta-APP695) displaying both intracellular and extracellular deposits of amyloid-beta-peptide (Abeta), intracellular accumulations of tau-protein and ubiquitin, a strong astrocytic response and acetylcholinesterase (AChE)-rich pyramidal neurons. The high amino acid homology (97.5%) between deguAbeta and humanAbeta sequences is probably a major factor in the appearance of AD markers in this aged rodent. Our results indicate that aged O. degu constitutes the first wild-type rodent model for neurodegenerative processes associated to AD.

Original publication




Journal article


Neurobiol Aging

Publication Date





1023 - 1028


Acetylcholinesterase, Aging, Alzheimer Disease, Amino Acid Sequence, Amyloid beta-Peptides, Animals, Astrocytes, Blotting, Northern, Brain, Disease Models, Animal, Gene Expression Regulation, Glial Fibrillary Acidic Protein, Humans, Immunohistochemistry, Neurons, Octodon, RNA, Messenger, Rats, Reverse Transcriptase Polymerase Chain Reaction, Ubiquitin, tau Proteins