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Calcium and cyclic AMP are familiar second messengers that typically become elevated inside cells on activation of cell surface receptors. This article will explore emerging evidence that transport of these signaling molecules across the plasma membrane allows them to be recycled as "third messengers," extending their ability to convey information in a domain outside the cell.

Original publication

DOI

10.1152/physiol.00019.2007

Type

Journal article

Journal

Physiology (Bethesda)

Publication Date

10/2007

Volume

22

Pages

320 - 327

Keywords

Animals, Autocrine Communication, Biological Transport, Calcium, Cell Membrane, Cyclic AMP, Extracellular Space, Humans, Paracrine Communication, Receptors, Calcium-Sensing, Receptors, Cyclic AMP, Second Messenger Systems