Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we will assume that you are happy to receive all cookies and you will not see this message again. Click 'Find out more' for information on how to change your cookie settings.

Sleep is a vital, evolutionarily conserved phenomenon, whose function is unclear. Although mounting evidence supports a role for sleep in the consolidation of memories, until now, a molecular connection between sleep, plasticity, and memory formation has been difficult to demonstrate. We establish Drosophila as a model to investigate this relation and demonstrate that the intensity and/or complexity of prior social experience stably modifies sleep need and architecture. Furthermore, this experience-dependent plasticity in sleep need is subserved by the dopaminergic and adenosine 3',5'-monophosphate signaling pathways and a particular subset of 17 long-term memory genes.

Original publication

DOI

10.1126/science.1130408

Type

Journal article

Journal

Science

Publication Date

22/09/2006

Volume

313

Pages

1775 - 1781

Keywords

Animals, Brain Chemistry, Circadian Rhythm, Cyclic AMP, Dopamine, Drosophila melanogaster, Female, Hearing, Learning, Male, Memory, Models, Animal, Mutation, Sexual Behavior, Animal, Signal Transduction, Sleep, Smell, Social Environment, Social Isolation, Vision, Ocular