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The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10)). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.

Original publication

DOI

10.1038/ng.251

Type

Journal article

Journal

Nat Genet

Publication Date

12/2008

Volume

40

Pages

1402 - 1403

Keywords

Case-Control Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Introns, Kinesin, Multiple Sclerosis