Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we will assume that you are happy to receive all cookies and you will not see this message again. Click 'Find out more' for information on how to change your cookie settings.

A novel mathematical model for hepatocytes and surrounding volume is presented here; in addition to tracking ion transport and diffusion the new model allows for changing cell volume. Using temporally and spatially varying temperature as an input, this paper shows how differences between diffusion coefficients directly influence increases in cell volume. The multiscale nature of the model presents a possible link from established cellular equations to the observed clinical result of oedema present in thermal treatments of cancer.

Original publication

DOI

10.1109/IEMBS.2011.6091069

Type

Journal article

Journal

Conf Proc IEEE Eng Med Biol Soc

Publication Date

2011

Volume

2011

Pages

4305 - 4308

Keywords

Cell Size, Edema, Fever, Humans, Models, Theoretical