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Central to the neural mechanism of MPTP-induced parkinsonism is overactivity of the subthalamic nucleus. Lesion of the subthalamic nucleus has therefore been performed in two primates with this condition and found to produce a remarkable amelioration of the disorder.

Original publication

DOI

10.1002/mds.870060404

Type

Journal article

Journal

Mov Disord

Publication Date

1991

Volume

6

Pages

288 - 292

Keywords

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Brain Mapping, Dominance, Cerebral, Macaca fascicularis, Neurologic Examination, Parkinson Disease, Secondary, Radiosurgery, Thalamic Nuclei