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We describe a tool, THoR, that automatically creates and curates multiple sequence alignments representing protein domains. This exploits both PSI-BLAST and HMMER algorithms and provides an accurate and comprehensive alignment for any domain family. The entire process is designed for use via a web-browser, with simple links and cross-references to relevant information, to assist the assessment of biological significance. THoR has been benchmarked for accuracy using the SMART and pufferfish genome databases.

Original publication




Journal article


Genome Biol

Publication Date





Algorithms, Animals, Benchmarking, Databases, Protein, Fish Proteins, Genome, Internet, Peptides, Protein Structure, Tertiary, Sequence Alignment, Sequence Homology, Amino Acid, Software, Tetraodontiformes