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We describe a tool, THoR, that automatically creates and curates multiple sequence alignments representing protein domains. This exploits both PSI-BLAST and HMMER algorithms and provides an accurate and comprehensive alignment for any domain family. The entire process is designed for use via a web-browser, with simple links and cross-references to relevant information, to assist the assessment of biological significance. THoR has been benchmarked for accuracy using the SMART and pufferfish genome databases.

Original publication

DOI

10.1186/gb-2003-4-8-r52

Type

Journal article

Journal

Genome Biol

Publication Date

2003

Volume

4

Keywords

Algorithms, Animals, Benchmarking, Databases, Protein, Fish Proteins, Genome, Internet, Peptides, Protein Structure, Tertiary, Sequence Alignment, Sequence Homology, Amino Acid, Software, Tetraodontiformes