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We have identified a family of 'Agenet' domains that are plant-specific homologs of Tudor domains. This finding has been extended, using a combination of sequence- and structure-dependent approaches, to show that the three beta-stranded core regions of Tudor, PWWP, chromatin-binding (Chromo) and MBT domains are homologous because they originate from a common ancestor. In addition, we have revealed pairs of tandem repeats in the fragile X mental retardation protein (FMRP) family that are also members of this Tudor domain 'Royal Family'.

Original publication




Journal article


Trends Biochem Sci

Publication Date





69 - 74


Amino Acid Sequence, Animals, Arabidopsis, Drosophila Proteins, Evolution, Molecular, Humans, Insect Proteins, Membrane Transport Proteins, Minisatellite Repeats, Models, Molecular, Molecular Sequence Data, Plant Proteins, Protein Structure, Secondary, Protein Structure, Tertiary, Sequence Homology, Amino Acid