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A family of membrane-associated proteins related to yeast Lag1p and mammalian TRAM has been identified. The family includes the protein product of CLN8, a gene mutated in progressive epilepsy with mental retardation. Mouse CLN8 is also mutated in the mnd/mnd mouse, a model for neuronal ceroid lipofuscinoses. The identification of these homologues has potential implications for our understanding of ceramide synthesis, lipid regulation and protein translocation in the endoplasmic reticulum.


Journal article


Trends Biochem Sci

Publication Date





381 - 383


Amino Acid Sequence, Animals, Fungal Proteins, Humans, Lipid Metabolism, Membrane Glycoproteins, Membrane Proteins, Membrane Transport Proteins, Mice, Molecular Sequence Data, Mutation, Protein Structure, Tertiary, Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid