Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we will assume that you are happy to receive all cookies and you will not see this message again. Click 'Find out more' for information on how to change your cookie settings.

A family of membrane-associated proteins related to yeast Lag1p and mammalian TRAM has been identified. The family includes the protein product of CLN8, a gene mutated in progressive epilepsy with mental retardation. Mouse CLN8 is also mutated in the mnd/mnd mouse, a model for neuronal ceroid lipofuscinoses. The identification of these homologues has potential implications for our understanding of ceramide synthesis, lipid regulation and protein translocation in the endoplasmic reticulum.



Trends Biochem Sci

Publication Date





381 - 383


Amino Acid Sequence, Animals, Fungal Proteins, Humans, Lipid Metabolism, Membrane Glycoproteins, Membrane Proteins, Membrane Transport Proteins, Mice, Molecular Sequence Data, Mutation, Protein Structure, Tertiary, Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid