Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we will assume that you are happy to receive all cookies and you will not see this message again. Click 'Find out more' for information on how to change your cookie settings.

A novel domain (the BRICHOS domain) of approximately 100 amino acids has been identified in several previously unrelated proteins that are linked to major diseases. These include BRI(2), which is related to familial British and Danish dementia (FBD and FDD); Chondromodulin-I (ChM-I), related to chondrosarcoma; CA11, related to stomach cancer; and surfactant protein C (SP-C), related to respiratory distress syndrome (RDS). In several of these, the conserved BRICHOS domain is located in the propeptide region that is removed after proteolytic processing. Experimental data suggest that the role of this domain could be related to the complex post-translational processing of these proteins.


Journal article


Trends Biochem Sci

Publication Date





329 - 332


Amino Acid Motifs, Amino Acid Sequence, Animals, Dementia, Humans, Infant, Newborn, Intercellular Signaling Peptides and Proteins, Membrane Proteins, Molecular Sequence Data, Neoplasm Proteins, Neoplasms, Protein Structure, Tertiary, Pulmonary Surfactants, Respiratory Distress Syndrome, Newborn, Sequence Alignment