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Cardiac action potential simulations were done with the stoichiometry of the Na/Ca exchanger set a 4: 1. Using the Hilgemann-Noble (1987) model, this stoichiometry reduces the resting potential unless regulation by intracellular calcium is incorporated. The K(d) required for such regulation is consistent with current experimental estimates of this parameter.

Type

Journal article

Journal

Ann N Y Acad Sci

Publication Date

11/2002

Volume

976

Pages

133 - 136

Keywords

Action Potentials, Animals, Guinea Pigs, Heart, Heart Atria, Heart Ventricles, Kinetics, Models, Cardiovascular, Sodium-Calcium Exchanger