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Cardiac action potential simulations were done with the stoichiometry of the Na/Ca exchanger set a 4: 1. Using the Hilgemann-Noble (1987) model, this stoichiometry reduces the resting potential unless regulation by intracellular calcium is incorporated. The K(d) required for such regulation is consistent with current experimental estimates of this parameter.


Journal article


Ann N Y Acad Sci

Publication Date





133 - 136


Action Potentials, Animals, Guinea Pigs, Heart, Heart Atria, Heart Ventricles, Kinetics, Models, Cardiovascular, Sodium-Calcium Exchanger