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POTRA (for polypeptide-transport-associated domain) is a novel domain identified in proteins of the ShlB, Toc75, D15 and FtsQ/DivIB families. In most cases, the POTRA domain is associated with a beta-barrel outer membrane domain and its function has been experimentally related to polypeptide transport in Toc75 (Tic-Toc protein import system in chloroplast) and ShlB families. In addition to potential key roles in protein transport across the outer membrane and in bacterial septation, the POTRA domain has attractive features for vaccine development in diseases such as cholera, meningitis, gonorrhoea and syphilis.

Type

Journal article

Journal

Trends Biochem Sci

Publication Date

10/2003

Volume

28

Pages

523 - 526

Keywords

Amino Acid Motifs, Amino Acid Sequence, Bacterial Proteins, Catalytic Domain, Cell Membrane, Escherichia coli Proteins, Membrane Proteins, Molecular Sequence Data, Protein Structure, Secondary, Protein Structure, Tertiary, Protein Transport