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Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson's disease and related disorders. Here, we summarize our non-human primate and neuroimaging research of relevance to our surgical targeting of the PPN. We also describe our clinical experience of PPN DBS with greatest motor improvements achieved by stimulation at low frequencies.

Original publication

DOI

10.1080/02688690802448335

Type

Journal article

Journal

Br J Neurosurg

Publication Date

2008

Volume

22 Suppl 1

Pages

S41 - S44

Keywords

Animals, Deep Brain Stimulation, Diffusion Magnetic Resonance Imaging, Parkinson Disease, Pedunculopontine Tegmental Nucleus, Primates