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The deep layers of the mammalian cerebral cortex contain pyramidal neurons that project predominantly to subcortical targets. To understand the mechanisms that determine the identity of deeper layer neurons, a PCR based subtractive hybridisation was performed to isolate genes that are specifically expressed during the specification of these neurons. One of the genes we isolated was the rat homologue of the mouse Slap-1. SLAP-1 is an adaptor protein containing SH2-SH3 domains and it participates in the signalling of Receptor Tyrosine Kinases. In situ hybridisation studies have shown that Slap-1 is not substantially expressed before E17. At later stages, it is specifically and selectively expressed by deeper layer neurons and by neurons of layers II/III in the developing cortex. The specific timing and location of its expression, suggests that this gene may play a role in the differentiation of these neurons.

Type

Journal article

Journal

Gene Expr Patterns

Publication Date

08/2003

Volume

3

Pages

437 - 440

Keywords

Adaptor Proteins, Signal Transducing, Animals, Animals, Newborn, Cell Differentiation, Cerebral Cortex, DNA, Complementary, Gene Expression Regulation, Developmental, In Situ Hybridization, Mice, Molecular Sequence Data, Neurons, Proto-Oncogene Proteins pp60(c-src), RNA, Messenger, Rats, Rats, Sprague-Dawley, Receptor Protein-Tyrosine Kinases, src Homology Domains