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K(ATP) channel openers are a diverse group of drugs with a wide range of potential therapeutic uses. Their molecular targets, the K(ATP) channels, exhibit tissue-specific responses because they possess different types of regulatory sulfonylurea receptor subunits. It is well recognized that complex interactions occur between K(ATP) channel openers and nucleotides, but the cloning of the K(ATP) channel has introduced a new dimension to the study of these events and has furthered our understanding of the molecular basis of the action of K(ATP) channel openers.

Type

Journal article

Journal

Trends Pharmacol Sci

Publication Date

11/2000

Volume

21

Pages

439 - 445

Keywords

Adenosine Triphosphate, Animals, Binding Sites, Cromakalim, Diazoxide, Humans, Minoxidil, Nicorandil, Pinacidil, Potassium Channels