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Blood vessels play a critical role in regulating neural stem cell proliferation and migration. We show here that blood vessels became progressively aligned in the direction of the rostral migratory stream (RMS) from embryonic day 14 to postnatal day 4. Dividing cells revealed by phosphohistone H3+ immunoreactivity were statistically closer to isolectin B4+ blood vessels than predicted by chance in the emerging RMS. The close proximity of blood vessels and H3+ cells was consistent regardless of the age of the RMS and was strikingly similar to the embryonic cerebral cortex. In contrast to the adult RMS, we found no evidence for preferential juxtaposition of migratory doublecortin-positive neuroblasts and vasculature in the neonatal RMS. Our work provides an important framework for understanding the precise mechanism behind regulation of proliferation.

Original publication

DOI

10.1159/000301135

Type

Journal article

Journal

Dev Neurosci

Publication Date

08/2010

Volume

32

Pages

163 - 172

Keywords

Animals, Blood Vessels, Brain, Cell Movement, Cell Proliferation, Cerebrovascular Circulation, Mice, Mice, Inbred C57BL, Neural Stem Cells, Neurogenesis