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Migraine is a common debilitating neurological disease characterised by attacks of severe headache with or without preceding aura. Its aetiology remains elusive; however it is clear that an interplay of genetic and environmental components play an important role. Familial hemiplegic migraine (FHM) is a rare and severe variant of migraine with aura and follows an autosomal dominant pattern of inheritance. This disease is genetically heterogeneous,with three causative genes having been identified. This review uses insights garnered from FHM to try and shed light on possible migraine disease pathogenesis.

Original publication

DOI

10.1007/s00415-007-0641-5

Type

Journal article

Journal

J Neurol

Publication Date

12/2007

Volume

254

Pages

1629 - 1635

Keywords

Humans, Migraine Disorders