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We discovered a thalidomide analogue [5-hydroxy-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione (5HPP-33)] with antiproliferative activity against nine cancer cell lines in vitro. Flow cytometric analyses showed that the compound caused G2-M arrest, which occurred mainly at the mitotic phase. In addition, immunofluorescence microscopy and in vitro tubulin polymerization studies showed that 5HPP-33 has antimicrotubule activity with a paclitaxel-like mode of action. It is effective against four different paclitaxel-resistant cell lines. Thus, 5HPP-33 represents a potential antitumor agent.

Original publication

DOI

10.1158/1535-7163.MCT-05-0254

Type

Journal article

Journal

Mol Cancer Ther

Publication Date

02/2006

Volume

5

Pages

450 - 456

Keywords

Animals, Antimitotic Agents, Antineoplastic Agents, Cell Cycle, Cell Line, Tumor, Drug Resistance, Neoplasm, Humans, Indoles, Isoindoles, Mice, Paclitaxel, Tubulin, Tubulin Modulators