Kalla M., Hao G., Tapoulal N., Tomek J., Liu K., Woodward L., ‘Oxford Acute Myocardial Infarction (OxAMI) Study’ None., Dall'Armellina E., Banning AP., Choudhury RP., Neubauer S., Kharbanda RK., Channon KM., Ajijola OA., Shivkumar K., Paterson DJ., Herring N.

AIMS: ST-elevation myocardial infarction is associated with high levels of cardiac sympathetic drive and release of the co-transmitter neuropeptide Y (NPY). We hypothesized that despite beta-blockade, NPY promotes arrhythmogenesis via ventricular myocyte receptors. METHODS AND RESULTS: In 78 patients treated with primary percutaneous coronary intervention, sustained ventricular tachycardia (VT) or fibrillation (VF) occurred in 6 (7.7%) within 48 h. These patients had significantly (P

The cardiac sympathetic co-transmitter neuropeptide Y is pro-arrhythmic following ST-elevation myocardial infarction despite beta-blockade.

Kalla M., Hao G., Tapoulal N., Tomek J., Liu K., Woodward L., ‘Oxford Acute Myocardial Infarction (OxAMI) Study’ None., Dall'Armellina E., Banning AP., Choudhury RP., Neubauer S., Kharbanda RK., Channon KM., Ajijola OA., Shivkumar K., Paterson DJ., Herring N.

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