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Nicotinic acid adenine dinucleotide phosphate (NAADP) is a recently described Ca2+ mobilizing messenger, and probably the most potent. We briefly review its unique properties as a Ca2+ mobilizing agent. We present arguments for its action in targeting acidic calcium stores rather than the endoplasmic reticulum. Finally, we discuss possible biosynthetic pathways for NAADP in cells and candidates for its target Ca2+ release channel, which has eluded identification so far.

Original publication

DOI

10.1111/j.1742-4658.2005.04860.x

Type

Journal article

Journal

FEBS J

Publication Date

09/2005

Volume

272

Pages

4598 - 4606

Keywords

Animals, Calcium, Calcium Signaling, Cyclic ADP-Ribose, Humans, Inositol 1,4,5-Trisphosphate, NADP, Second Messenger Systems