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Mitochondrial Ca(2+) uptake shapes the profile of intracellular Ca(2+) signals, both spatially and temporally. In addition, such uptake controls the gating of Ca(2+) release and store-operated Ca(2+) entry channels, partitions cells into subcellular Ca(2+) hotspots, and can result in the release of diffusible signals into the cytosol that subsequently regulate protein function.

Type

Journal article

Journal

News Physiol Sci

Publication Date

12/2003

Volume

18

Pages

252 - 256

Keywords

Animals, Buffers, Calcium, Calcium Signaling, Intracellular Membranes, Mitochondria