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Novel targeted fluorescent biosensors provide key insights into very local nanodomains of cAMP and PKA activity, and how they respond differently to β-adrenergic activation in cardiac myocytes. This unique spatiotemporal detail in living cells is not available with biochemical measurements of total cellular cAMP and PKA, and provides unique physiological insights.

Original publication

DOI

10.1152/physiol.00002.2019

Type

Journal article

Journal

Physiology (Bethesda)

Publication Date

01/07/2019

Volume

34

Pages

240 - 249