{ "items": [ "\n\n
\n \n 8 June 2021\n \n
\n\n \n\n \n\n \n \n \n \n Cardiac Theme\n \n \n \n \n Postdoctoral\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nIn animal models, iron deficient mothers have a greatly increased risk of having offspring with congenital heart disease (CHD). The risk of CHD can be greatly reduced if the mother is given iron supplements very early in pregnancy. Additionally, embryos from a mouse model of Down Syndrome were particularly vulnerable to the effects of maternal iron deficiency, leading to a higher risk of developing severe heart defects.
\n \n\n\n \n 18 May 2021\n \n
\n\n \n\n \n\n \n \n \n \n Cell Physiology\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nA new study from the Parekh Group has resolved a long-standing question in our understanding of intracellular Ca2+ signalling, namely how a specific type of Ca2+ channel is uniquely able to signal to the nucleus to regulate gene expression. By unravelling this mechanism, researchers have identified a new approach for developing immunosuppressant drugs.
\n \n\n\n \n 17 May 2021\n \n
\n\n \n\n \n\n \n \n \n \n Lakhal-Littleton Group News\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nA new study from the Lakhal-Littleton Group has addressed a long-standing gap in our understanding of systemic iron homeostasis. It provides the first formal demonstration that the hormone hepcidin controls iron reabsorption in the kidney, in a manner that impacts the body\u2019s iron levels, under normal physiological conditions. It also demonstrates for the first time how this mechanism becomes critically important in the development of iron disorders.
\n \n\n\n \n 14 April 2021\n \n
\n\n \n\n \n\n \n \n \n \n Integrative Neuroscience\n \n \n \n \n Molnar Group News\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nA new study from the Moln\u00e1r group on the role of regulated synaptic vesicular release in specialised synapse formation has made it to the cover of Cerebral Cortex.
\n \n\n\n \n 7 April 2021\n \n
\n\n \n\n \n\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n \n \n Vyazovskiy Group News\n \n \n\n \n\n\n
\n \n\n \n \n \nA new study from the Vyazovskiy group suggests that how and where we spend our time while awake impacts how much we need to sleep - it does not only depend on how long we are awake.
\n \n\n\n \n 30 March 2021\n \n
\n\n \n\n \n\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n \n \n Smart Group News\n \n \n\n \n\n\n
\n \n\n \n \n \nA new study from the Smart group has shed light on a key regulatory step in the initiation and progression of Abdominal Aortic Aneurysm by revealing the protective role of a previously little known small protein.
\n \n\n\n \n 10 February 2021\n \n
\n\n \n\n \n\n \n \n \n \n Cell Physiology\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nA clinical trial has commenced this week to test whether a drug called almitrine can help people who are seriously ill with COVID-19 to recover from the disease.
\n \n\n\n \n 27 January 2021\n \n
\n\n \n\n \n\n \n \n \n \n CNCB\n \n \n \n \n Goodwin Group News\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nA new paper from the Goodwin group based in DPAG's Centre for Neural Circuits and Behaviour has shown how males and females are programmed differently in terms of sex.
\n \n\n\n \n 26 January 2021\n \n
\n\n \n\n \n\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n \n \n Wilson Group News\n \n \n\n \n\n\n
\n \n\n \n \n \nThe transfer of complex mixtures of signals and nutrients between individuals is a key step in several biologically important events in our lives, such as breastfeeding and sexual intercourse. However, we know relatively little about the ways in which the molecular gifts involved are packaged to ensure their successful delivery to the recipient.
\n \n\n\n \n 21 January 2021\n \n
\n\n \n\n \n\n \n \n \n \n EDI News\n \n \n \n \n Outreach\n \n \n \n \n Postdoctoral\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nUniversity of Oxford researchers from the Department of Physiology, Anatomy and Genetics (DPAG) and the Department of Psychiatry, in collaboration with The 1928 Institute, have published a major new study on the impact of COVID-19 on the UK\u2019s largest BME population.
\n \n\n\n \n 8 January 2021\n \n
\n\n \n\n \n\n \n \n \n \n Postdoctoral\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n \n \n Srinivas Group news\n \n \n\n \n\n\n
\n \n\n \n \n \nThe earliest known progenitor of the outermost layer of the heart has been characterised for the first time and linked to the development of other critical cell types in the developing heart in a new paper from the Srinivas group led by BHF Immediate Fellow Dr Richard Tyser.
\n \n\n\n \n 2 December 2020\n \n
\n\n \n\n \n\n \n \n \n \n Postdoctoral\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nIn a new study into the longer-term damage amongst patients recovering from COVID-19, DPAG Research Fellow Dr James Grist of the Tyler Lab has been running a novel scanning technique that shows a dramatic decrease in the ability of the lungs to diffuse gas in to the blood stream after COVID infection. This work may shed light on the problem of breathlessness after COVID infection and help guide us in understanding therapeutic selection and efficacy.
\n \n\n\n \n 27 November 2020\n \n
\n\n \n\n \n\n \n \n \n \n CNCB\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nHundreds of dietary supplements have been reported to improve cognitive and emotional function in humans, but few have scientific foundation. A new study from the Waddell group provides fresh insight into how dietary Magnesium supplementation can influence memory performance.
\n \n\n\n \n 19 November 2020\n \n
\n\n \n\n \n\n \n \n \n \n Cardiac Theme\n \n \n \n \n Postdoctoral\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nNew research led by Oxford BHF CRE Intermediate Transition Fellow Dr Kerstin Timm shows that a recently developed imaging technique pioneered by the Tyler Group can detect early metabolic changes in the heart caused by a commonly used chemotherapy drug, which is known to increase risk of heart failure in cancer survivors.
\n \n\n\n \n 23 October 2020\n \n
\n\n \n\n \n\n \n \n \n \n Integrative Neuroscience\n \n \n \n \n Postdoctoral\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n \n \n Students\n \n \n\n \n\n\n
\n \n\n \n \n \nA computational modelling study from the King Group demonstrates that the way sounds are transformed from the ear to the brain\u2019s auditory cortex may be simpler than expected. These findings not only highlight the value of computational modelling for determining the principles underlying neural processing, but could also be useful for improving treatments for patients with hearing loss.
\n \n\n\n \n 21 October 2020\n \n
\n\n \n\n \n\n \n \n \n \n Cell Physiology\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n \n \n Students\n \n \n\n \n\n\n
\n \n\n \n \n \nThe Zaccolo Group has identified a new mechanism that regulates mitochondria quality control, a process that is crucial to maintaining healthy cells and preventing disease.
\n \n\n\n \n 16 October 2020\n \n
\n\n \n\n \n\n \n \n \n \n CNCB\n \n \n \n \n Postdoctoral\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nA new study by Waddell Group Neuroscientists at the Centre for Neural Circuits and Behaviour shows that mobile genetic elements that were active in the genomes of our ancestors could be closely linked to important functions in our brain and might help diversify our behaviour, cognition and emotions.
\n \n\n\n \n 16 October 2020\n \n
\n\n \n\n \n\n \n \n \n \n Integrative Neuroscience\n \n \n \n \n Molnar Group News\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nTransient neurones match the spontaneous and sensory driven activities to shape cortical circuits: a landmark collaborative review published in Science from Professor Zolt\u00e1n Moln\u00e1r, Professor Patrick Kanold and Professor Heiko Luhmann.
\n \n\n\n \n 2 October 2020\n \n
\n\n \n\n \n\n \n \n \n \n Cragg Group News\n \n \n \n \n OPDC News\n \n \n \n \n Postdoctoral\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n \n \n Wade-Martins Group News\n \n \n\n \n\n\n
\n \n\n \n \n \nA new collaborative study from the Oxford Parkinson\u2019s Disease Centre led by Prof Stephanie Cragg and Dr Bradley Roberts has revealed that GABA transporters on astrocytes, the brain's lesser known yet critically important cells, support dopamine release and are sites of early dysfunction in parkinsonism.
\n \n\n\n \n 28 September 2020\n \n
\n\n \n\n \n\n \n \n \n \n OPDC News\n \n \n \n \n Postdoctoral\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n \n \n Wade-Martins Group News\n \n \n\n \n\n\n
\n \n\n \n \n \nA collaborative study led by the OPDC's Dr Nora Bengoa-Vergniory has shown that compounds known as molecular tweezers could become a promising disease modifying therapy for Parkinson\u2019s.
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