{ "items": [ "\n\n
\n \n 1 July 2020\n \n
\n\n \n\n \n\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n \n \n Vyazovskiy Group News\n \n \n\n \n\n\n
\n \n\n \n \n \nAssociate Professor Vladyslav Vyazovskiy has edited a special issue of Current Opinion of Physiology with Professor A. Jennifer Morton from the University of Cambridge. \u201cPhysiology of Sleep\u201d compiles the latest developments in sleep research around the complex question of \u2018why do we sleep?\u2019
\n \n\n\n \n 18 June 2020\n \n
\n\n \n\n \n\n \n \n \n \n Lakhal-Littleton Group News\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nA key hormone in the fetal liver has been found for the first time to play a critical role in determining iron endowment in the newborn baby. Up until now, widely held notions made in comparison to how the adult liver controls iron in the body have led to a common focus on how maternal iron status and function of the placenta determines a baby's iron status. A new study from the Lakhal-Littleton group reveals a more autonomous process takes place within the fetus than previously understood.
\n \n\n\n \n 12 June 2020\n \n
\n\n \n\n \n\n \n \n \n \n Cell Physiology\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nThe destruction of red blood cells known as hemolysis in the newborn baby is very dangerous, but existing clinical methods are not sufficient for rapid diagnosis and can lead to delays early-life care. A new Swietach Group paper has identified a biomarker that could significantly speed up the process.
\n \n\n\n \n 26 May 2020\n \n
\n\n \n\n \n\n \n \n \n \n Cardiac Theme\n \n \n \n \n Herring Group News\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nDPAG researchers have collaborated on an international study that demonstrates a detailed mechanistic understanding of how the anti-malaria drug, Hydroxychloroquine, combined with antibiotics, can cause adverse cardiac side-effects in COVID-19 patients. This gives weight to US Federal advice against using this combined treatment.
\n \n\n\n \n 22 May 2020\n \n
\n\n \n\n \n\n \n \n \n \n CNCB\n \n \n \n \n Goodwin Group News\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nThe collaborating groups of Professor Stephen Goodwin and Professor Scott Waddell based in The Centre for Neural Circuits and Behaviour (CNCB) are shedding new light on what precisely constitutes a neuronal cell type.
\n \n\n\n \n 13 May 2020\n \n
\n\n \n\n \n\n \n \n \n \n Domingos Group News\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nA collaborative research team from the Universities of Oxford and Cambridge co-led by DPAG's Associate Professor Ana Domingos have developed a new weight-loss amphetamine that could potentially avoid the harmful side effects of traditional treatments.
\n \n\n\n \n 27 April 2020\n \n
\n\n \n\n \n\n \n \n \n \n Mommersteeg Group News\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nNew collaborative research from the Mommersteeg Group and MRC WIMM researchers shows that a protein called Runx1 plays a significant role in the formation of the cardiac scar that forms after the heart is injured, a scar that is known to inhibit heart regeneration. In the zebrafish, a freshwater fish known to be able to fully regenerate its heart after damage, they show that the absence of Runx1 results in enhanced regeneration. This indicates a potential new therapeutic target for heart repair.
\n \n\n\n \n 23 April 2020\n \n
\n\n \n\n \n\n \n \n \n \n Cell Physiology\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nDPAG scientists develop single-cell oxygen saturation imaging to study oxygen handling by red blood cells. New physiological techniques that measure the blood's oxygen saturation are particularly important in light of the current pandemic, as COVID-19 patients present an abnormally low concentration of oxygen in the blood.
\n \n\n\n \n 31 January 2020\n \n
\n\n \n\n \n\n \n \n \n \n Cardiac Theme\n \n \n \n \n Postdoctoral\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nDPAG's Dr Jakub Tomek and Professor Blanca Rodriguez's Computational Cardiovascular Science Team have developed a new computer model that recreates the electrical activity of the ventricles in a human heart. In doing so, they have uncovered and resolved theoretical inconsistencies that have been present in almost all models of the heart from the last 25 years and created a new human heart model that could enable more basic, translational and clinical research into a range of heart diseases and potentially accelerate the development of new therapies.
\n \n\n\n \n 30 January 2020\n \n
\n\n \n\n \n\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n \n \n Riley Group News\n \n \n \n \n Simoes Group News\n \n \n\n \n\n\n
\n \n\n \n \n \nAn immune cell is shown for the first time to be involved in creating the scar that repairs the heart after damage. The Riley Group study was funded by the British Heart Foundation and led by BHF CRE Intermediate Transition Research Fellow Dr Filipa Sim\u00f5es.
\n \n\n\n \n 16 January 2020\n \n
\n\n \n\n \n\n \n \n \n \n Integrative Neuroscience\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nWe experience a wide range of sounds at varying levels. The brain's auditory neurons constantly adapt their responses to changes in sound level to help us perceive and understand what we hear. King Group researchers have previously demonstrated how these neurons do this and have now produced new evidence for exactly where this happens in the brain and the perceptual consequences of these adaptations.
\n \n\n\n \n 15 January 2020\n \n
\n\n \n\n \n\n \n \n \n \n Integrative Neuroscience\n \n \n \n \n Molnar Group News\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nThe severity of Zika virus-related deformations in babies has been shown to be affected by environmental factors such as maternal nutrition. The study was partially funded by a joint MRC Grant between DPAG's Professor Zolt\u00e1n Moln\u00e1r and Associate Professor Patricia Garcez of the Federal University of Rio de Janeiro.
\n \n\n\n \n 10 January 2020\n \n
\n\n \n\n \n\n \n \n \n \n Domingos Group News\n \n \n \n \n Postdoctoral\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nA news and views article published in Nature Immunology by Domingos Group researchers examines significant recent research revealing how group 3 innate lymphoid cells (ILC3s), the cells responsible for protecting the gut and maintaining intestinal homeostasis, are regulated. In doing so, they also reveal important new research avenues of ILCs activation in the body.
\n \n\n\n \n 8 January 2020\n \n
\n\n \n\n \n\n \n \n \n \n Cardiac Theme\n \n \n \n \n Herring Group News\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nFor many years, we have been using beta-blockers to neutralise a specific stress hormone and prevent dangerous heart rhythms following a heart attack. However, a new study led by Associate Professor Neil Herring and published in the European Heart Journal has uncovered evidence for an additional stress hormone acting as a key trigger for dangerous heart rhythms that is not currently targeted by these drugs.
\n \n\n\n \n 7 January 2020\n \n
\n\n \n\n \n\n \n \n \n \n Cardiac Theme\n \n \n \n \n Herring Group News\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nUCLA Researchers in collaboration with DPAG researchers from the Paterson and Herring Groups have identified a biomarker for increased risk of early mortality in patients with heart failure. Associate Professor Neil Herring is senior author.
\n \n\n\n \n 19 December 2019\n \n
\n\n \n\n \n\n \n \n \n \n Integrative Neuroscience\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nA new study led by Dr Armin Lak suggests that we learn best when we make decisions outside of our comfort zone, and sheds light on how the brain might achieve this.
\n \n\n\n \n 11 December 2019\n \n
\n\n \n\n \n\n \n \n \n \n Domingos Group News\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nA new review from the Domingos Lab, authored by Chelsea Larabee, Oliver Neeley and Ana Domingos, examines the intersection between neuroimmunology and immunometabolism, and in doing so reveals the existence of an exciting new area of study.
\n \n\n\n \n 10 December 2019\n \n
\n\n \n\n \n\n \n \n \n \n Domingos Group News\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nAssociate Professor Ana Domingos reviews the identification of the hormone leptin and explores its significance in the function of immune cells in obesity.
\n \n\n\n \n 4 November 2019\n \n
\n\n \n\n \n\n \n \n \n \n Cragg Group News\n \n \n \n \n OPDC News\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n \n \n Wade-Martins Group News\n \n \n\n \n\n\n
\n \n\n \n \n \nOur Researchers at the Oxford Parkinson\u2019s Disease Centre have shown that cell recycling in Parkinson\u2019s may play a more complex role than previously thought.
\n \n\n\n \n 25 October 2019\n \n
\n\n \n\n \n\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n \n \n Wilson Group News\n \n \n\n \n\n\n
\n \n\n \n \n \nA new collaborative study involving DPAG's Wilson and Goberdhan Groups and the Nuffield Department of Surgical Sciences (NDS) has revealed surprising parallels between \u2018prostate\u2019 cells in flies and cancer patients.
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